Results
| PMID | 15694967 |
| Gene Name | KIT |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 87 |
| Population details | 87 (9 women with endometriosis, 18 women without endometriosis, 20 peritoneal endometriosis, 20 ovarian endometriosis, 20 colorectal endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
J Reprod Immunol. 2005 Feb;65(1):55-63. Uzan, Catherine| Cortez, Annie| Dufournet, Charlotte| Fauvet, Raffaele| Siffroi, Jean-Pierre| Darai, Emile Service d'Anatomie Pathologie, Hopital Tenon, AP-HP, 4 rue de la Chine, 75020 Paris, France. BACKGROUND: Endometriosis is defined by the presence of endometrium outside the uterus. Changes in the expression of the proto-oncogene c-kit are associated with aggressive behaviour of both benign and malignant tumours, but there are few data on its c-kit expression in endometriosis. Here we examined c-kit expression in endometrium and endometriotic tissue. METHODS: Immunohistochemistry was used for qualitative and semi-quantitative (mean+/-S.D. positive cells) analysis of c-kit expression in endometrium from women with (n=9) and without endometriosis (n=18), and in peritoneal (n=20), ovarian (n=20) and colorectal endometriosis (n=20). RESULTS: Semi-quantitative c-kit expression was higher in endometrial glandular cells from women with endometriosis than from women without endometriosis (15.0+/-14.6% versus 3.9+/-7.4%, p=0.01). No difference in c-kit expression was found in qualitative analysis and according to the phase of the menstrual cycle. C-kit expression values in peritoneal, ovarian and colorectal endometriosis were 2.0+/-3.8%, 2.0+/-4.1% and 21.7+/-18.4%, respectively. Qualitative and semi-quantitative c-kit expression was higher in colorectal endometriosis than in peritoneal and ovarian endometriosis (p<0.001); no difference was found between ovarian and peritoneal endometriosis. No c-kit expression was detected in stromal cells of either endometrium or endometriotic tissue. CONCLUSION: These results suggest that the c-kit/stem cell factor axis is involved in the pathogenesis of endometriosis. Strong c-kit protein expression was associated with invasive endometriotic lesions. Mesh Terms: Adult| Colon/metabolism/pathology| Endometriosis/*metabolism/pathology| Endometrium/*metabolism/pathology| Female| *Gene Expression Regulation| Humans| Ovary/metabolism/pathology| Peritoneum/metabolism/pathology| Proto-Oncogene Proteins c-kit/*bi |
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