Results
| PMID | 15733405 |
| Gene Name | TIMP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 77 |
| Population details | 77 (45 patients with endometriosis (study group), in 32 patients with uterine fibroid (control group)) |
| Sex | Female |
| Associated genes | MMP-9, TIMP-1 |
| Other associated phenotypes |
Ectopic endometriosis |
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Zhonghua Fu Chan Ke Za Zhi. 2004 Dec;39(12):809-12. Chen, Qiong-hua| Qu, Jun-ying| Xu, Ya-yun| Qiu, Na-xuan| Zhuang, Yan-zhen| Zhong, Shan| Fang, Qing-quan Department of Obstetrics and Gynecology, First Affiliated Hospital in Xiamen, Fujian Xiamen 361004, China. OBJECTIVE: To study the expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ectopic and eutopic endometrium in patients with endometriosis. METHODS: The expressions of MMP-9 and TIMP-1 in ectopic and eutopic endometrium were detected by immunohistochemistry streptavidin-biotin peroxidase (SP) method in 45 patients with endometriosis (study group) and in 32 patients with uterine fibroid (control group). RESULTS: In the ectopic and eutopic endometrium of group and in the control group endometrium, the expression of MMP-9 was respectively 0.381, 0.336 and 0.276; the expression of TIMP-1 was respectively 0.239, 0.253, 0.267. As a result, the ratio of MMP-9/TIMP-1 in ectopic and eutopic endometrium of study group and in the control group endometrium was respectively 1.594, 1.293, 1.034. The difference of MMP-9, MMP-9/TIMP-1 in ectopic and eutopic and the control group endometrium was markedly significant (P < 0.01 or P < 0.05). The difference of the expression of TIMP-1 between ectopic and the control group endometrium was also markedly significant (P < 0.01). Higher expression of MMP-9 and lower expression of TIMP-1 in ectopic endometrium and higher expression of MMP-9 in eutopic endometrium occurred in the whole menses period, in which higher expression of MMP-9 in ectopic endometrium than in eutopic endometrium only took place in proliferative phase. CONCLUSION: The change of expression of MMP-9 and TIMP-1 in ectopic endometrium may be related to the pathogenesis of endometriosis. Mesh Terms: Adult| Endometriosis/*enzymology/pathology| Endometrium/*enzymology/pathology| Female| Humans| Immunohistochemistry| Matrix Metalloproteinase 9/*metabolism| Menstrual Cycle/metabolism| Tissue Inhibitor of Metalloproteinase-1/*metabolism|DA 2005/11 |
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