Results
| PMID | 15837658 |
| Gene Name | CXCL5 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 67 |
| Population details | 67 (42 patients with endometriosis (20 in stages I and II, 22 in stages III and IV), 25 women without endometriosis (control group)) |
| Sex | Female |
| Associated genes | ENA-78 |
| Other associated phenotypes |
Endometriosis |
|
Di Yi Jun Yi Da Xue Xue Bao. 2005 Apr;25(4):464-5. Cai, Zhu-Hua| He, Yuan-Li| Peng, Dong-Xian Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. caizhua12@hotmail.com OBJECTIVE: To investigate the role of serum epithelial neutrophil-activating peptide-78 (ENA-78) in the pathogenesis of endometriosis. METHODS: Serum concentrations of ENA-78 were measured by means of enzyme-linked immunosorbent assay (ELISA) in 42 patients with endometriosis (20 in stages I and II and 22 in stages III and IV) in comparison with 25 women without endometriosis (control group). RESULTS: Serum concentrations of ENA-78 were significantly higher in endometriosis group than in the control group (2.97+/-1.91 ng/ml vs 0.72+/-0.24 ng/ml, P>0.001), and ENA-78 levels in stages III and IV were significantly higher than those in stages I and II (4.48+/-1.25 ng/ml vs 1.30+/-0.74 ng/ml, P>0.001). Significant difference in ENA-78 levels between follicular phase and luteal phase was found in neither of the groups. CONCLUSION: Patients with endometriosis have elevated serum ENA-78 levels, which might be a pathogenic factor of endometriosis. Mesh Terms: Adult| Chemokine CXCL5| Chemokines, CXC/*blood| Endometriosis/*blood| Female| Humans| Middle Aged|DA 2007/05/02 09:00 |
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