Results
| PMID | 15871199 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 67 |
| Population details | 67 (30 patients with ovarian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Feb;30(1):92-5. Fan, Hong| Fang, Xiao-ling Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, China. fanwentao2002@yahoo.com.cn OBJECTIVE: To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis. METHODS: Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were enrolled it determine the expression of COX-2 immunohistochemically in eutopic or ectopic endometrium or healthy endometrial tissues. RESULTS: The immunoreactivities of COX-2 were found in epithelial cells and stromal cells in eutopic endometrium. The expression of COX-2 in the epithelial cells in the secretory phase was higher than that in the proliferative phase in the control group and ovarian endometriosis group (P <0. 05). But the expression of COX-2 in stromal cells in the control group and ovarian endometriosis group showed no cyclic changes throughout the menstrual cycle (P > 0. 05). The expression of COX-2 in eutopic and ectopic endometrium in the ovarian endometriosis group was higher than that in the control group (P <0. 05) , hut we did not find significant difference between the eutopic and ectopic endometrium in the ovarian endometriosis group (P > 0. 05). CONCLUSION: The increased COX-2 expression in eutopic and ectopic endometrium in ovarian endometriosis may he related to its pathology. Mesh Terms: Adult| Cyclooxygenase 2/*biosynthesis/genetics| Endometriosis/*enzymology| Endometrium/*enzymology| Female| Humans| Immunohistochemistry| Ovarian Diseases/*enzymology|DA 2006/08/11 09:00 |
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