Results
| PMID | 15940796 |
| Gene Name | IL16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 44 |
| Population details | 44 (22 women with different stage endometriosis, 22 controls) |
| Sex | Female |
| Associated genes | IL-16 |
| Other associated phenotypes |
Endometriosis |
|
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 May;34(3):260-2. Lin, Jun| Zhang, Xin-mei| Deng, Lin| Chen, Zheng-yun| Chen, Li The Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China. OBJECTIVE: To investigate the role of interleukine-16 (IL-16) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of IL-16 in peritoneal fluid and serum specimens of 22 women with different stage endometriosis and 22 controls. RESULTS: The median levels of IL-16 in peritoneal fluid and serum were 290.5 pg/ml and 539.4 pg/ml in women with endometriosis, and 296.6 pg/ml and 778.1 pg/ml in controls, respectively; there was no significant difference between two groups (P>0.05). However, the IL-16 levels in peritoneal fluid and serum of patients with minimal/mild stage endometriosis and controls were all significantly higher than those of patients with moderate/severe endometriosis (P<0.01, <0.05). In addition, there was no statistical correlation of peritoneal IL-16 levels with those in serum (P>0.05). CONCLUSION: Reduced levels of IL-16 in peritoneal fluid and serum of women with advanced stage endometriosis may imply a role of IL-16 in the development and progression of endometriosis. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Endometriosis/*metabolism| Female| Humans| Interleukin-16/*analysis/blood| Middle Aged|DA 2005/11/16 09:00 |
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