Results
| PMID | 15979990 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 103 |
| Population details | 103 (71 endometriomas (group 1), 32 peritoneal implants and or recto-vaginal nodules (group 2) of endometriotic tissue from 85 patients submitted to complete laparoscopic ablation of severe endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Hum Reprod. 2005 Oct;20(10):2964-8. Epub 2005 Jun 24. Fanfani, Francesco| Fagotti, Anna| Ferrandina, Gabriella| Bifulco, Giuseppe| Legge, Francesco| Lorusso, Domenica| Minelli, Luca| Scambia, Giovanni Department of Oncology, Division of Gynaecologic Oncology, Catholic University of Sacred Heart, Campobasso, Italy. BACKGROUND: Recent studies have demonstrated the overexpression of cyclooxygenase-2 (COX-2) in endometriosis. The aim of this study was to investigate the correlation between COX-2 expression and the clinical outcome rate in a homogeneous series of patients undergoing fertility-sparing complete laparoscopic ablation for severe endometriosis. METHODS: COX-2 expression was analysed by immunohistochemistry in 103 samples, 71 endometriomas (group 1) and 32 peritoneal implants and or recto-vaginal nodules (group 2) of endometriotic tissue from 85 patients submitted to complete laparoscopic ablation of severe endometriosis. RESULTS: At median follow-up of 54 months, a recurrence rate of 24.7% (n = 21) was observed. Patients with COX-2-positive endometriotic cysts showed a lower relapse rate than COX-2-negative cases (16.7 versus 41.2%; P = 0.036). Patients with COX-2-positive peritoneal implant and or recto-vaginal nodule showed a similar trend. Taking the two groups of patients together, we found a significantly lower relapse rate in COX-2-positive patients in comparison to COX-2-negative patients (16.4 versus 40%; P = 0.0152). Moreover, COX-2-positive patients showed a longer relapse-free survival in comparison to COX-2-negative patients (P = 0.016). CONCLUSIONS: In patients with severe endometriosis who underwent fertility-sparing complete ablation, COX-2 overexpression characterizes a subgroup of patients with lower risk of relapse and longer relapse-free survival. Mesh Terms: Adult| Cyclooxygenase 2/*biosynthesis| Disease-Free Survival| Endometriosis/*enzymology/*surgery| Endometrium/diagnostic imaging/enzymology/pathology| Female| Follow-Up Studies| *Gene Expression Regulation, Enzymologic| Humans| Immunohistochemist |
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