Results
| PMID | 16305697 |
| Gene Name | CXCL6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 64 |
| Population details | 64 (38 women with endometriosis, 26 cystadenomas) |
| Sex | Female |
| Associated genes | GCP-2 |
| Other associated phenotypes |
Endometriosis |
|
Acta Obstet Gynecol Scand. 2005 Dec;84(12):1141-4. Suzumori, Nobuhiro| Zhao, Xaio Xi| Suzumori, Kaoru Department of Obstetrics & Gynecology, Nagoya City University Graduate School of Medicine, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan. og.n.suz@med.nagoya-cu.ac.jp BACKGROUND: To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle. METHODS: Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay. RESULT: Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis. CONCLUSION: Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2. Mesh Terms: Adult| Ascitic Fluid/metabolism| Case-Control Studies| Chemokine CXCL6| Chemokines, CXC/*metabolism| Chemotaxis, Leukocyte| Endometriosis/*metabolism/pathology/*physiopathology/surgery| Enzyme-Linked Immunosorbent Assay| Female| Granulocytes| Hu |
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