Results
| PMID | 16309818 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 70 |
| Population details | 70 (20 peritoneal endometriosis, 19 ovarian endometriosis, 31 deep-infiltrating endometriosis ) |
| Sex | Female |
| Associated genes | COX-2 |
| Other associated phenotypes |
Endometriotic lesions |
|
Eur J Obstet Gynecol Reprod Biol. 2006 Feb 1;124(2):216-21. Epub 2005 Nov 22. Buchweitz, Olaf| Staebler, Annette| Wulfing, Pia| Hauzman, Erik| Greb, Robert| Kiesel, Ludwig Department of Obstetrics and Gynecology, University of Munster, Albert Schweitzer Str. 33, D-48149 Munster, Germany. buchweo@mednet.uni-muenster.de OBJECTIVE: To investigate cyclooxygenase (COX-2) expression within different endometriotic lesions and to assess whether these expression patterns correlate with clinical characteristics. DESIGN: Retrospective cross-sectional study. SETTING: University Hospital. PATIENTS: Seventy patients with histologically confirmed exclusively peritoneal (n=20), ovarian (n=19) or deep-infiltrating (n=31) endometriosis and a detailed medical history. INTERVENTION: Immunohistochemical analysis for COX-2 was performed on 108 endometriotic lesions. MEASUREMENTS AND MAIN RESULTS: COX-2 intensity, percentage of stained glandular endometriotic cells, and correlation of COX-2 expression with clinicopathological parameters. Semiquantitative COX-2 expression did not differ between distinct morphological types of endometriosis and showed no association with the menstrual cycle. Patients with peritoneal-only endometriosis suffering from moderate or severe chronic pelvic pain showed significantly more frequent COX-2 overexpression than asymptomatic patients or patients with minimal symptoms. In patients with exclusively ovarian or deep-infiltrating endometriosis no association between COX-2 expression and clinical parameters, such as chronic pelvic pain, dysmenorrhoea, dyspareunia, sterility, lower urinary tract symptoms or gastrointestinal symptoms was observed. CONCLUSION: Peritoneal endometriotic lesions with increased COX-2 expression have a special relevance for the development of chronic, nonmenstruation-associated, pelvic pain in endometriotic patients. These patients may benefit from therapy with COX-2 inhibitors. Mesh Terms: Chronic Disease| Cross-Sectional Studies| Cyclooxygenase 2/analysis/*biosynthesis| Endometriosis/complications/*enzymology| Female| Humans| Immunohistochemistry| Pelvic Pain/*etiology| Peritoneal Cavity/*pathology| Peritoneal Diseases/complicatio |
|