Results
| PMID | 16522409 |
| Gene Name | FGF2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 39 |
| Population details | 39 (25 women with endometriosis, 14 healthy controls) |
| Sex | Female |
| Associated genes | FGF-2 |
| Other associated phenotypes |
Endometriosis |
|
Am J Obstet Gynecol. 2006 Mar;194(3):755-9. Bourlev, Vladimir| Larsson, Anders| Olovsson, Matts Research Centre of Obstetrics, Gynaecology and Perinatology, Russian Academy of the Medical Sciences, Moscow, Russia. OBJECTIVE: The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor-2 (FGF-2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF-2 in serum and peritoneal fluid. STUDY DESIGN: Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF-2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls. RESULTS: Patients with endometriosis had higher serum concentrations of FGF-2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF-2 differed significantly between women with high and low proliferative activity in their endometriotic lesions. CONCLUSION: Women with endometriosis have a higher serum level of FGF-2 than healthy controls. Mesh Terms: Adult| Ascitic Fluid/chemistry| Biomarkers/analysis| Cell Proliferation| Endometriosis/*blood/pathology| Female| Fibroblast Growth Factor 2/analysis/*blood| Humans|DA 2006/05/17 09:00 |
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