Results
| PMID | 16533339 |
| Gene Name | FAS |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | CD56, CD95, CD69 |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2006 Apr;55(4):276-81. Eidukaite, Audrone| Siaurys, Almantas| Tamosiunas, Vytas Department of Molecular Immunology, Institute of Immunology, Vilnius, Lithuania. elza@takas.lt PROBLEM: Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis. METHOD: Two-colour flow cytometry was used. RESULTS: In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high. CONCLUSION: Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease. Mesh Terms: Adult| Antigens, CD/*biosynthesis| Antigens, CD56/*biosynthesis| Antigens, CD95/*biosynthesis| Antigens, Differentiation, T-Lymphocyte/*biosynthesis| Ascitic Fluid/cytology/immunology| Endometriosis/*immunology/*metabolism/pathology| Female| Human |
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