Results
| PMID | 16580392 |
| Gene Name | NOS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 49 |
| Population details | 49 (30 patients with endometriosis-associated infertility, 19 patients with carcinoma in situ of the cervix) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis associated infertility |
|
Fertil Steril. 2006 Apr;85(4):1037-44. Wang, JianHua| Zhou, FuZhen| Dong, MinYue| Wu, RuiJin| Qian, YuLi Department of Reproductive Endocrinology, Women's Hospital, The School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. OBJECTIVE: To determine whether endometrial expression of endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS) protein in women with endometriosis-associated infertility is different from that in the fertile controls, whether GnRH agonist (GnRH-a) regulates the endometrial expression of NOS in women with endometriosis-associated infertility, and whether there is a correlation between serum E2 or P levels, and the endometrial expression of eNOS or iNOS. DESIGN: Prospective controlled study. SETTING: University hospital for reproductive medicine and gynecologic endocrinology. PATIENT(S): Thirty patients with endometriosis-associated infertility and 19 patients with carcinoma in situ of the cervix. INTERVENTION(S): Endometrial biopsy specimens and blood samples. MAIN OUTCOME MEASURE(S): Endometrial eNOS and iNOS protein relative levels and serum concentrations of E2 or P. RESULT(S): By Western blot analysis, iNOS was not detected, and a unique menstrual cycle-dependent expression of eNOS was observed. Eutopic endometrium in women with endometriosis-associated infertility before GnRH-a treatment showed higher levels of eNOS than that of the control group. After 3 months of GnRH-a therapy, eNOS levels in the endometrium were reduced. In addition, a significant positive correlation was found between serum E2 or P concentrations, and the endometrial expression of eNOS. CONCLUSION(S): The GnRH-a treatment attenuated the endometrial expression of eNOS in women with endometriosis-associated infertility. Endogenous ovarian steroids influence endometrial eNOS expression. Mesh Terms: Adult| Endometriosis/drug therapy/*enzymology| Endometrium/drug effects/*enzymology| Female| Gene Expression Regulation, Enzymologic/drug effects/physiology| Gonadotropin-Releasing Hormone/*administration & dosage/*agonists| Humans| Infertility, Fe |
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