Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 16635455
Gene Name TNFRSF11B
Condition Endometriosis
Association Associated
Population size 132
Population details 132 (77 women were diagnosed with endometriosis, 55 women were free of the disease and served as control subjects)
Sex Female
Associated genes PAPPA, glycodelin, osteoprotegerin, CD163
Other associated phenotypes Endometriosis
PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis.

Am J Obstet Gynecol. 2006 Jul;195(1):103-8. Epub 2006 Apr 25.

Bersinger, Nick A| von Roten, Stephanie| Wunder, Dorothea M| Raio, Luigi| Dreher, Ekkehard| Mueller, Michael D

Endometriosis Centre, Department of Obstetrics and Gynaecology, University of Berne, Switzerland.

OBJECTIVE: The purpose of this study was to evaluate whether pregnancy-associated plasma protein A, glycodelin, osteoprotegerin, and soluble CD163 are possible peritoneal fluid markers for endometriosis and to compare them with the established chemokine markers interleukin-8 and regulated on activation, normal T-cell expressed and secreted. STUDY DESIGN: Determination of the concentrations of interleukin-8, regulated on activation, normal T-cell expressed and secreted, pregnancy-associated plasma protein A, glycodelin, CD163, osteoprotegerin, and progesterone in the peritoneal fluid collected from women undergoing laparoscopy. RESULTS: From a total of 132 women, 77 women were diagnosed with endometriosis, and 55 women were free of the disease and served as control subjects. Pregnancy-associated plasma protein A and osteoprotegerin showed significantly (P < 0.05) elevated peritoneal fluid concentrations as a function of the severity of the disease, together with interleukin-8 and regulated on activation, normal T-cell expressed and secreted (P < .001). Glycodelin and CD163 did not differ between cases and control subjects. Many of these marker concentrations were intercorrelated strongly. CONCLUSION: Pregnancy-associated plasma protein A and osteoprotegerin may play a role in the inflammation process of endometriosis, but interleukin-8 and regulated on activation, normal T-cell expressed and secreted are superior peritoneal fluid markers.

Mesh Terms: Adult| Ascitic Fluid/*chemistry| Chemokine CCL5/*analysis| Endometriosis/*metabolism| Female| Glycoproteins/*analysis| Humans| Interleukin-8/*analysis| Osteoprotegerin| Pregnancy-Associated Plasma Protein-A/*analysis| Receptors, Cytoplasmic and