Results
| PMID | 16708809 |
| Gene Name | CYP2B6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 58 |
| Population details | 58 (36 endometriosis women, 22 non-endometriosis but subfertility or pelvic pain women served as controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | P450, CA125 |
| Other associated phenotypes |
Endometriosis, Subfertility |
|
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec;30(6):682-5. Zeng, Fei| Xue, Min Department of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha 410013, China. zengfeilyx@163.com OBJECTIVE: To evaluate the diagnostic value of examining endometrial biopsy specimens for aromatase cytochrome P450 and CA125 for endometriosis. METHODS: The expression of aromatase cytochrome P450 in endometrium was detected by immunohistochemical analysis for 36 endometriosis women and 22 non-endometriosis but subfertility or pelvic pain women served as controls; the serum CA125 levels were measured by chemical radiation method. RESULTS: By measuring serum CA125, the sensitivity of the serum CA125 assay was 44%, the specificity was 82%, the positive predictive value was 80%, and the negative predictive value was 47%; the sensitivity of aromatase cytochrome P450 in biopsy endometrium of endometriosis was 82%, the specificity was 59%, the positive predictive value was 76%, and the negative predictive value was 67%. CONCLUSION: The combination assay of aromatase cytochrome P450 in eutopic endometrium and CA125 can be used as a diagnostic test for endometriosis, especially for the early stage of endometriosis, which is superior to the assay of CA125. Mesh Terms: Adult| Aromatase/*analysis| Biopsy, Needle| CA-125 Antigen/*analysis| Endometriosis/*diagnosis| Endometrium/*chemistry| Female| Humans| Sensitivity and Specificity|DA 2006/09/13 09:00 |
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