Results
| PMID | 16997300 |
| Gene Name | CCL5 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 60 |
| Population details | 60 (32 women with endometriosis stages I-IV, 28 women without endometriosis) |
| Sex | Female |
| Associated genes | RANTES, MCP-1 |
| Other associated phenotypes |
Endometriosis, Tubal infertility |
|
Fertil Steril. 2006 Dec;86(6):1616-20. Epub 2006 Sep 25. Xu, Hong| Schultze-Mosgau, Askan| Agic, Admir| Diedrich, Klaus| Taylor, Robert N| Hornung, Daniela Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Luebeck, Germany. OBJECTIVE: To compare the amount of regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) in follicular fluid (FF) of patients with and without endometriosis and to determine their oocyte fertilization and pregnancy rates. DESIGN: Case-control study. SETTING: Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Campus Luebeck, Germany. PATIENT(S): Thirty-two women with endometriosis stages I-IV and 28 women without endometriosis, both groups surgically and histologically confirmed. INTERVENTION(S): Diagnostic laparoscopy, IVF-ET. MAIN OUTCOME MEASURE(S): RANTES and MCP-1 levels in follicular fluid, measured by ELISA, and oocyte fertilization and pregnancy rates. RESULT(S): Follicular response and days of gonadotropin stimulation were similar between the two groups. The levels of RANTES in FF from patients with endometriosis were significantly higher (460.4 +/- 90.3 pg/mL) compared with concentrations in patients with tubal infertility (243.8 +/- 70.9 pg/mL; P<.05). In contrast, MCP-1 concentrations in FF from women with endometriosis (330.0 +/- 29.2 pg/mL) were lower than in women with tubal infertility (420.5 +/- 46.6 pg/mL; P<.05). Oocyte fertilization rates in the endometriosis group (54%) were significantly lower than those of the tubal infertility group (73%; P<.05), as were the pregnancy rates (19% vs. 35%, respectively; P<.01). CONCLUSION(S): Women with endometriosis-associated infertility have a poor IVF outcome. Immune cell recruitment into the ovary might affect follicular function and lead to impaired oocyte quality. Mesh Terms: Adult| Chemokine CCL2/*immunology| Chemokine CCL5/*immunology| Endometriosis/complications/*immunology| Female| *Fertilization in Vitro| Follicular Fluid/*immunology| Humans| Infertility, Female/etiology/*immunology/*therapy| Lymphocyte Activatio |
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