Results
| PMID | 17357296 |
| Gene Name | CCL19 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 43 |
| Population details | 43 (25 infertile women with endometriosis, 18 contro) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | MDC/CCL22, TARC/CCL17, MCP-1/CCL2, RANTES/CCL5, MIP-1alpha/CCL3, -1beta/CCL4, -1delta/CCL15, -3alpha/CCL20, and -3beta/CCL19. |
| Other associated phenotypes |
Endometriosis associated infertility, primary infertility |
|
Adv Med Sci. 2006;51:148-52. Laudanski, P| Szamatowicz, J| Oniszczuk, M Department of Pathophysiology of Pregnancy, Medical University of Bialystok, Poland. plauda@cksr.ac.bialystok.pl PURPOSE: Chemokines play essential role not only in controlling leukocyte function and trafficking but also in the angiogenesis and modulation of inflammatory responses. MATERIAL AND METHODS: A novel array-based enzyme-linked immunosorbent assay was used to quantitate peritoneal fluid chemokines of 25 infertile women with endometriosis and 18 controls. For our preliminary studies we chose mini-array containing nine different chemokines: MDC/CCL22, TARC/CCL17, MCP-1/CCL2, RANTES/CCL5, MIP-1alpha/CCL3, -1beta/CCL4, -1delta/CCL15, -3alpha/CCL20, and -3beta/CCL19. RESULTS: We found significantly higher MIP-3beta/CCL19 (P = 0.0036) concentrations in peritoneal fluid of women with endometriosis as compared to patients with primary infertility without any signs of disease. CONCLUSIONS: Our preliminary results suggest that MIP-3beta/ /CCL19 might play a role in the pathogenesis of endometriosis but its precise role remains to be established. Novel types of screening methods based on high-throughput technologies offer great opportunities to study immunobiology of endometriosis. It will hopefully provide new possibilities for discovery of new markers and potential drug targets. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Chemokines/*metabolism| Endometriosis/*metabolism/pathology| Enzyme-Linked Immunosorbent Assay/methods| Female| Humans| Infertility, Female/metabolism/pathology|DA 2007/07/06 09:00 |
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