Results
| PMID | 17578349 |
| Gene Name | PDGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 66 |
| Population details | 66 (35 women with advanced stage endometriosis, 31 control women) |
| Sex | Female |
| Associated genes | EGF, FGF-2, PDGF-A |
| Other associated phenotypes |
Endometriosis |
|
J Obstet Gynaecol Res. 2007 Jun;33(3):242-7. Lee, Sa-Ra| Kim, Sung-Hoon| Lee, Young-Jin| Hong, Seok-Ho| Chae, Hee-Dong| Kim, Chung-Hoon| Kang, Byung-Moon| Choi, Young-Min Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. AIM: The objective of the present study was to compare the levels of expression of epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), and platelet-derived growth factor-A (PDGF-A) mRNA in the eutopic endometrium of women with and without endometriosis. METHODS: Thirty-five women with advanced stage endometriosis and 31 control women were recruited. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified to quantify the level of expression of EGF, FGF-2, PDGF-A. RESULTS: While the levels of mRNA of EGF and FGF-2 were not different between the two groups, the PDGF-A mRNA level was significantly lower in the endometriosis group than in the control group during the secretory phase (6.12 +/- 0.51 vs 12.50 +/- 0.99, mean +/- SEM, P < 0.05). CONCLUSION: The expression level of PDGF-A, but not EGF and FGF-2, might be decreased during the secretory phase in the eutopic endometrium of women with advanced stage endometriosis. Mesh Terms: Adult| Case-Control Studies| Endometriosis/*metabolism| Endometrium/*metabolism| Epidermal Growth Factor/*metabolism| Female| Fibroblast Growth Factor 2/*metabolism| Humans| Luteal Phase/metabolism| Platelet-Derived Growth Factor/*metabolism|DA 2 |
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