Results
| PMID | 17767060 |
| Gene Name | LTA |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | TNF-beta (+252 site) |
| Population size | 162 |
| Population details | 162 (82 patients with endometriosis (the endometriosis group), 80 patients without endometriosis (the control group)) |
| Sex | Female |
| Associated genes | TNF-beta |
| Other associated phenotypes |
Endometriosis |
|
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):656-9. Luo, Min| Shen, Dong-Xiang| Zhang, Hong-Bin| Wang, Jie| Zong, Li-Li| Guan, Ting| He, Yuan-Li Department of Obstetrics and Gynecology, General Hospital of Guangzhou Military Area Command, Guangzhou 510010, China. OBJECTIVE: To determine the polymorphism in +252 site of tumor necrosis factor-beta(TNF-beta) gene in patients with or without endometriosis, to evaluate the levels of TNF-alpha and TNF-beta in the serum with or without endometriosis, to explore the relation between polymorphism of TNF-beta gene and the genetic susceptibility of endometriosis, and to explore the pathogenic mechanism of endometriosis at gene level. METHODS: By polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, polymorphism on +252 site of TNF-beta gene was measured in 82 patients with endometriosis (the endometriosis group) and 80 patients without endometriosis (the control group). With the sandwich-enzyme-linked immunosorbent assay (ELISA), the levels of TNF-alpha and TNF-beta in the serum of the two groups were determined. RESULTS: The TNF-beta level in the serum in the endometriosis group with TNF-beta gene +252 site AA genotype significantly increased, compared with GG genotype (t=2.029, P<0.05); while TNF-alpha and TNF-beta level in the serum had no statistical significance in patients with other genotypes in TNF-beta gene +252 site in the endometriosis group and the control group. CONCLUSION: TNF-beta gene +252 site AA genotype might be enhance TNF-beta level in the serum of patients with endometriosis. Mesh Terms: Adolescent| Adult| Endometriosis/*blood/genetics| Female| Humans| Lymphotoxin-alpha/*blood/*genetics| *Polymorphism, Genetic| Tumor Necrosis Factor-alpha/*blood| Young Adult|DA 2014/03/13 06:00 |
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