Results
| PMID | 17888430 |
| Gene Name | MMP9 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 55 |
| Population details | 55 (25 with endometriosis, 30 without endometriosis) |
| Sex | Female |
| Associated genes | c-fos, MMP-9 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2008 Oct;90(4):1000-7. Epub 2007 Sep 20. Pan, Hong| Sheng, Jian-Zhong| Tang, Li| Zhu, Rong| Zhou, Tian-Hua| Huang, He-Feng Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. OBJECTIVE: To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN: Molecular studies in human tissue. SETTING: A women's hospital in China. PATIENT(S): Fifty-five premenopausal women (25 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery or hysterectomy. INTERVENTION(S): Eutopic and ectopic endometrium tissue were obtained at the time of surgery. Peripheral sera were also collected on the same day. MAIN OUTCOME MEASURE(S): Immunohistochemical localization of c-fos in the endometrium, c-fos and MMP-9 protein levels in the endometrium, and 17beta-E(2) levels in the serum. RESULT(S): c-fos protein was predominantly located in the nuclei of glandular epithelial cells and stromal cells. c-fos and MMP-9 protein levels in paired eutopic and ectopic endometria from women with endometriosis were significantly higher than those in the endometrium from women without endometriosis. No significant difference in c-fos or MMP-9 protein levels was observed between paired eutopic and ectopic endometria. c-fos protein levels in endometrium positively correlated with endometrial MMP-9 levels and serum 17beta-E(2) levels. CONCLUSION(S): Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants. Mesh Terms: Adult| Endometriosis/*metabolism| Endometrium/*metabolism| Estradiol/*metabolism| Female| Humans| Matrix Metalloproteinase 9/*metabolism| Menstrual Cycle/metabolism| Middle Aged| Ovarian Diseases/*metabolism| Proto-Oncogene Proteins c-fos/*metab |
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