Results
| PMID | 18177649 |
| Gene Name | TIMP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | MMP-2 (-1306C-->T, -735C-->T), TIMP-2 (-418G-->C) |
| Sex | Female |
| Associated genes | MMP-2, TIMP-2 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2008 Nov;90(5):2023-9. doi: 10.1016/j.fertnstert.2007.09.068. Epub Kang, Shan| Zhao, Xi-Wa| Wang, Na| Chen, Shu-Cheng| Zhou, Rong-Miao| Li, Yan Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China. We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North Chinese women. Mesh Terms: Adult| Asian Continental Ancestry Group/*genetics| Case-Control Studies| China/epidemiology| Endometriosis/enzymology/ethnology/*genetics| Female| Gene Frequency| Genetic Predisposition to Disease| Humans| Linkage Disequilibrium| Matrix Metallop |
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