Results
| PMID | 18928861 |
| Gene Name | NPY |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 49 |
| Population details | 49 (20 of them with deep endometriosis in the uterosacral ligament and 29 patients without endometriosis) |
| Sex | Female |
| Associated genes | NSE, NPY, VIP |
| Other associated phenotypes |
Endometriosis |
|
J Reprod Immunol. 2008 Oct;79(1):93-9. doi: 10.1016/j.jri.2008.08.004. Kelm Junior, Adolpho Roberto| Lancellotti, Carmen Lucia P| Donadio, Nilson| Auge, Antonio Pedro F| Lima, Sonia Maria Rolim R| Aoki, Tsutomu| Ribeiro, Paulo Ayroza OB/Gyn Department, Santa Casa Medical School, Sao Paulo, Brazil. adolphojr@uol.com.br UNLABELLED: Endometriosis is a disease of high prevalence and enigmatic origin. One aspect not yet clarified is the relationship between endometriosis and nerve tissue. OBJECTIVE: To evaluate, by immunohistochemistry, the presence of sympathetic and parasympathetic nerve fibers in the uterosacral ligament and adjacent connective tissue in women with deep pelvic endometriosis and women without endometriosis. DESIGN: Cross-sectional study (Canadian Task Force II). SETTING: University Hospital. Obstetrics and Gynecology Department, Santa Casa Medical School, Sao Paulo, Brazil. METHODOLOGY: We selected 49 patients, 20 of them with deep endometriosis in the uterosacral ligament and 29 patients without endometriosis. Secondary antibodies to NSE (pan-neuronal marker), NPY (that identifies sympathetic nerve fibers), and VIP (that identifies parasympathetic nerve fibers) were used for the immunohistochemistry analyses. RESULTS: The immunohistochemical staining by the NSE antibody was positive in 40% of cases of women with endometriosis and in 20.7% of patients without endometriosis (non-significant). The immunohistochemical staining by the NPY antibody was positive in 60% of patients with endometriosis and in 20.7% of the control group (p=0.005), while staining by the VIP antibody was 60% in patients with endometriosis and 13.8% in patients without endometriosis (p=0.001). CONCLUSION: Immunoexpression of NPY (sympathetic fibers) and VIP (parasympathetic fibers) is higher in women with deep pelvic endometriosis than in women without endometriosis. Mesh Terms: Adult| Cross-Sectional Studies| Endometriosis/*etiology/pathology| Female| Humans| Immunohistochemistry| Ligaments/*innervation| Nerve Fibers/*chemistry| Neuropeptide Y/analysis| Phosphopyruvate Hydratase/analysis| Sacrum/innervation| Uterus/in |
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