Results
| PMID | 19232412 |
| Gene Name | CRP |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 82 |
| Population details | 82 (34 women with no endometriosis, 48 women with endometriosis) |
| Sex | Female |
| Associated genes | CRP |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2010 May 1;93(7):2125-9. doi: 10.1016/j.fertnstert.2009.01.072. Lermann, Johannes| Mueller, Andreas| Korber, Frauke| Oppelt, Peter| Beckmann, Matthias W| Dittrich, Ralf| Renner, Stefan P Department of Obstetrics and Gynecology, Erlangen University Hospital, D-91054 Erlangen, Germany. OBJECTIVE: To compare high-sensitivity C-reactive protein (hs-CRP) with CRP as a soluble serum marker for the diagnosis of women with endometriosis. DESIGN: Prospective nonrandomized controlled trial (Canadian Task Force classification II-1). SETTING: University hospital. PATIENT(S): Eighty-two women were laparoscopically evaluated. No endometriosis was diagnosed in 34 women (the non-E group). Endometriosis was confirmed by histology in 48 women (the E group). Eighty-two women did not undergo laparoscopic evaluation (the unknown-E group). Afterward, the women were staged according to the revised American Society for Reproductive Medicine criteria (r-ASRM). INTERVENTION(S): CRP and hs-CRP were measured initially before laparoscopy. MAIN OUTCOME MEASURE(S): The hs-CRP and CRP levels and the correlation of those parameters with the stage of the disease. RESULT(S): There was a trend toward higher CRP levels and higher hs-CRP levels in the E group, while the lowest levels of both markers were found in the non-E group. There was a significantly lower hs-CRP level in the non-E group in comparison with the CRP level in this group. No differences between the different stages of the disease were found with either marker. CONCLUSION(S): Measurement of the two markers did not appear to be advantageous for the diagnosis of endometriosis independent of the stage of the disease. Nevertheless, a very low hs-CRP level might serve as a marker for an absence of endometriosis. Mesh Terms: Adult| Biomarkers/analysis/blood| C-Reactive Protein/*analysis/chemistry| Diagnostic Techniques, Obstetrical and Gynecological| Disease Progression| Endometriosis/*blood/classification/*diagnosis/surgery| Female| Gynecologic Surgical Procedures/met |
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