Results
| PMID | 19260859 |
| Gene Name | SPP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 122 |
| Population details | 122 (79 patients with histologically confirmed endometriosis, 43 patients without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2009 Apr;61(4):286-93. doi: Cho, SiHyun| Ahn, Young Sun| Choi, Young Sik| Seo, Seok Kyo| Nam, Anna| Kim, Hye Yeon| Kim, Jae-Hoon| Park, Ki Hyun| Cho, Dong Jae| Lee, Byung Seok Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. PROBLEM: The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels in patients with endometriosis. METHOD OF STUDY: A total of 79 patients with histologically confirmed endometriosis and 43 patients without endometriosis participated in this study. OPN mRNA expression in endometrial tissues was measured by real-time quantitative polymerase chain reaction (PCR) and plasma concentrations of OPN were quantified using a specific commercial sandwich enzyme-linked immunosorbent assays (ELISA). RESULTS: Osteopontin mRNA expression in endometrial tissue was significantly higher in women with endometriosis than in controls (P = 0.010). The mean plasma levels of OPN (mean +/- S.E.M.) in patients with endometriosis and controls were 407.31 +/- 37.80 ng/mL and 165.84 +/- 19.29 ng/mL, respectively (P < 0.001). Receiver operating characteristic (ROC) analysis for plasma OPN revealed an area under the curve (AUC) of 0.894, with a sensitivity of 93.0%, specificity of 72.4%, positive likelihood ratio of 3.37, and negative likelihood ratio of 0.1 using a cut-off value of 167.68 ng/mL. CONCLUSION: Osteopontin may be involved in the pathogenesis of endometriosis and plasma OPN may be a useful non-invasive marker for the diagnosis of endometriosis. Mesh Terms: Adolescent| Adult| Biomarkers| CA-125 Antigen/genetics/*metabolism| Endometriosis/diagnosis/*metabolism/pathology/physiopathology| Endometrium/*metabolism| Enzyme-Linked Immunosorbent Assay| Female| Gene Expression Profiling| Humans| Middle Aged |
|