Results
| PMID | 19285664 |
| Gene Name | PROK1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 24 |
| Population details | 24 (12 patients affected by endometriosis, 12 control women) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2010 May 1;93(7):2145-9. doi: 10.1016/j.fertnstert.2009.01.105. Tiberi, Federica| Tropea, Anna| Apa, Rosanna| Romani, Federica| Lanzone, Antonio| Marana, Riccardo Istituto Scientifico Internazionale (ISI) Paolo VI, Universita Cattolica del Sacro Cuore (UCSC), 00168 Rome, Italy. fm1810@inwind.it OBJECTIVE: To examine prokineticin 1 (PROK1) mRNA expression in eutopic endometrial glands obtained from patients with or without endometriosis, to investigate the presence of additional endometrial abnormalities in women with endometriosis. DESIGN: Prospective laboratory study. SETTING: University hospital. PATIENTS: Twelve control women and 12 patients affected by endometriosis in the secretory phase of the menstrual cycle. INTERVENTION(S): Endometrial specimens were obtained from women affected (cases) or not (control group) by endometriosis. Endometrial glands were freshly isolated from endometrial biopsies. MAIN OUTCOME MEASURE(S): PROK1 mRNA expression levels by real-time polymerase chain reaction analysis. RESULTS: PROK1 mRNA was detectable in 4 of 12 (33%) samples obtained from women affected by endometriosis, whereas 10 of 12 (83%) samples obtained from normal women were positive for PROK1 detection by real-time polymerase chain reaction. Moreover, detectable PROK1 mRNA levels were 10 times lower in samples obtained from women with endometriosis than in samples obtained from control women. CONCLUSION(S): PROK1 is a newly discovered angiogenic factor implicated in the vascular function of peri-implantation endometrium and early pregnancy. An altered expression of PROK1 could be one of the several biochemical abnormalities characterizing eutopic endometrium in endometriosis. Mesh Terms: Adult| Biopsy| Endometriosis/*genetics/metabolism/pathology| Endometrium/*metabolism/pathology| Female| Health| Humans| Luteal Phase/genetics/metabolism| RNA, Messenger/metabolism| Uterine Diseases/*genetics/metabolism/pathology| Vascular Endoth |
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