Endometriosis Knowledgebase

PMID	19647233
Gene Name	PTGS2
Condition	Endometriosis
Association	Associated
Sex	Female
Associated genes	COX-2, PGE2
Other associated phenotypes	Endometriosis
Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression. Fertil Steril. 2010 Jan;93(1):325-7. doi: 10.1016/j.fertnstert.2009.06.042. Epub Takenaka, Yasuko\| Taniguchi, Fuminori\| Miyakoda, Hiroko\| Takai, Eri\| Terakawa, Naoki\| Harada, Tasuku Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan. Lipopolysaccharide-enhanced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production were compared in endometriotic stromal cells (ESCs) and eutopic endometrial stromal cells. Lipopolysaccharide promotes the proliferation and invasion of ESCs via up-regulation of COX-2 and PGE2 expression, suggesting that pelvic inflammation may promote the progression of endometriosis. Mesh Terms: Case-Control Studies\| Cell Movement/drug effects\| Cell Proliferation/drug effects\| Cells, Cultured\| Cyclooxygenase 2/*biosynthesis/genetics\| Cyclooxygenase 2 Inhibitors/pharmacology\| Dinoprostone/metabolism\| Dose-Response Relationship, Drug\| End