Results
| PMID | 19930843 |
| Gene Name | STAR |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 63 |
| Population details | 63 (38 cases of endometriosis with ectopic endometria, 25 normal endometria (controls)) |
| Sex | Female |
| Associated genes | SF-1, StAR |
| Other associated phenotypes |
Endometriosis |
|
J Int Med Res. 2009 Sep-Oct;37(5):1389-95. Tian, Yongjie| Kong, B| Zhu, W| Su, S| Kan, Y Department of Obstetrics and Gynaecology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. yiet@tom.com This study was designed to investigate the levels of expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis, and to explore the association between these two factors and the menstrual cycle and the severity of endometriosis. Levels of SF-1 and StAR protein were evaluated using immunohistochemistry in 38 cases of endometriosis with ectopic endometria and in 25 normal endometria (controls). The SF-1 and StAR protein levels were significantly higher in ectopic endometria than in normal endometria. There was a significant correlation between the level of SF-1 and StAR in ectopic endometriotic tissues. It is concluded that protein levels of SF-1 and StAR are upregulated in ectopic endometria and are significantly correlated with the severity of endometriosis. Mesh Terms: Adult| Case-Control Studies| Endometriosis/*metabolism/pathology| Endometrium/*metabolism/pathology| Female| Humans| Immunoenzyme Techniques| Ovarian Neoplasms/*metabolism/pathology| Peritoneal Neoplasms/*metabolism/pathology| Phosphoproteins/*me |
|