Results
| PMID | 20068324 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 47 |
| Population details | 47 (26 patients with endometriosis, 21 patients with other benign gynecological conditions) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Gynecol Obstet Invest. 2010;69(2):93-100. doi: 10.1159/000261017. Epub 2009 Nov Cho, SiHyun| Park, Soo Hyeon| Choi, Young Sik| Seo, Seok Kyo| Kim, Hye Yeon| Park, Ki Hyun| Cho, Dong Jae| Lee, Byung Seok Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Seoul, Korea. BACKGROUND/AIMS: The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameters. METHODS: Twenty-six patients with endometriosis and 21 patients with other benign gynecological conditions were enrolled. The eutopic endometrium was sampled by pipelle, and fragments of ovarian endometrioma and non-endometriotic ovarian cysts were sampled during surgery. Total RNA isolation and semiquantitative reverse transcriptase polymerase chain reaction was performed. RESULTS: The expression of Cox-2 mRNA (mean +/- SEM) in eutopic endometrium and ovarian endometriotic tissue significantly increased in patients with endometriosis compared with the controls. The expression of Cox-2 increased significantly in the proliferative phase in eutopic endometrium and in the secretory phase in ovarian endometriotic tissue of patients with endometriosis compared with the controls. Cox-2 mRNA expression in the endometrium and ovarian lesions significantly correlated with serum CA-125 and the diameter of the endometrioma. CONCLUSIONS: Cox-2 expression increased in the eutopic endometrium and ovarian endometriotic tissue of the patients with endometriosis. These findings indicate that Cox-2 may be involved in the pathogenesis and progression of endometriosis. Mesh Terms: Adult| CA-125 Antigen/blood| Cyclooxygenase 2/*biosynthesis/genetics| Endometriosis/blood/*enzymology/genetics| Female| Gene Expression Regulation, Enzymologic| Humans| Ovarian Diseases/blood/*enzymology/genetics| RNA, Messenger/biosynthesis/genet |
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