Results
| PMID | 20100617 |
| Gene Name | MMP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | MMP-2 (-735 C/T), MMP-9 (-1562 C/T) |
| Sex | Female |
| Associated genes | MMP-2, MMP-9 |
| Other associated phenotypes |
Endometriosis |
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Fertil Steril. 2010 Sep;94(4):1560-3. doi: 10.1016/j.fertnstert.2009.12.024. Epub Saare, Merli| Lamp, Merit| Kaart, Tanel| Karro, Helle| Kadastik, Ulle| Metspalu, Andres| Peters, Maire| Salumets, Andres Department of Obstetrics and Gynecology, University of Tartu, Tartu University Hospital's Women's Clinic, Tartu, Estonia. merli.saare@ut.ee In this case-control study, we investigated the potential associations of MMP-2 and MMP-9 gene promoter region polymorphisms as well as MMP-2 promoter haplotypes with susceptibility to endometriosis in women of caucasian origin. The results demonstrated that polymorphisms in MMP-2 (-735 C/T) and MMP-9 (-1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group. Mesh Terms: Adolescent| Adult| Case-Control Studies| Endometriosis/*genetics| Female| Genetic Linkage| Genetic Predisposition to Disease| Humans| Matrix Metalloproteinase 2/*genetics| Matrix Metalloproteinase 9/*genetics| Middle Aged| *Polymorphism, Geneti |
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