Results
| PMID | 20537326 |
| Gene Name | RAGE |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 48 |
| Population details | 48 (28 study patients, 20 controls) |
| Sex | Female |
| Associated genes | RAGE, EN-RAGE, COX-2 |
| Other associated phenotypes |
Endometriosis |
|
Int J Gynaecol Obstet. 2010 Sep;110(3):199-202. doi: 10.1016/j.ijgo.2010.03.037. Sharma, Indu| Dhawan, Veena| Saha, Subhash Chand| Rashmi, Bagga| Dhaliwal, Lakhbir Kaur Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. OBJECTIVE: To investigate the involvement of the receptor gene for advanced glycation (RAGE), its ligand EN-RAGE, and COX-2 in endometriosis. METHODS: The mRNA and protein expression of the corresponding genes were determined from endometriotic cells from 28 study patients and healthy endometrial stromal cells from 20 controls by semiquantitative RT-PCR and Western blot analysis, respectively, using beta-actin as an invariant control. RESULTS: The expression of COX-2, RAGE, and EN-RAGE was significantly increased, as evidenced by the significantly greater mRNA and protein expression in the cells of the study patients (P<0.001). Previous treatment for endometriosis did not lessen mRNA and protein expression (P<0.001). CONCLUSION: Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment. Mesh Terms: Adult| Advanced Glycosylation End Product-Specific Receptor| Case-Control Studies| Cyclooxygenase 2/genetics/*metabolism| Endometriosis/*metabolism| Endometrium/cytology/*metabolism| Female| Gene Expression| Humans| Receptors, Immunologic/genetic |
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