Results
| PMID | 20662556 |
| Gene Name | IL16 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-16 (rs4778889 T/C polymorphism, rs11556218 T/G polymorphism) |
| Population size | 433 |
| Population details | 433 (230 patients with endometriosis, 203 controls) |
| Sex | Female |
| Associated genes | IL-16 |
| Other associated phenotypes |
Endometriosis |
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DNA Cell Biol. 2010 Nov;29(11):663-7. doi: 10.1089/dna.2010.1049. Epub 2010 Jul Gan, Xiao-Ling| Lin, Yong-Hong| Zhang, Yi| Yu, Ting-He| Hu, Li-Na Department of Gynecology and Obstetrics, West China Secondary Hospital, Sichuan University, Chengdu, PR China. Interleukin-16 (IL-16), a proinflammatory cytokine, plays a pivotal role in inflammatory diseases as well as in the pathogenesis of endometriosis. The aim of this study was to evaluate the association of IL-16 gene polymorphisms with the risk and clinical phenotypes of endometriosis in Chinese women. We analyzed rs4778889 T/C, rs11556218 T/G polymorphisms of the IL-16 gene in 230 patients with endometriosis and 203 controls in a Chinese population, using a polymerase chain reaction-high resolution melting analysis strategy and DNA sequencing methods. There was no significant difference in the genotype and allele frequencies of the rs11556218 T/G polymorphism between patients with endometriosis and controls (p>0.05). In contrast, the genotype and allele frequencies of the rs4778889 T/C polymorphism were statistically different between patients with endometriosis and controls, which resulted from a significantly increased proportion of TC heterozygote and CC homozygote carriers among patients with endometriosis (p=0.001 and 0.012, respectively); moreover, further subgroup analysis found that the genotype difference was more evident in patients with endometriosis who also experienced pain symptoms (p<0.001) than in patients without pain symptoms (p=0.625) when compared with controls. Our results suggest that the rs4778889 T/C polymorphism of the IL-16 gene may be associated with risk of endometriosis in the Chinese population, especially in patients with pain phenotype. Mesh Terms: Adult| Endometriosis/*complications/*genetics| Female| Gene Frequency| Genetic Predisposition to Disease/*genetics| Humans| Interleukin-16/*genetics| Pain/*complications/*genetics| Phenotype| *Polymorphism, Single Nucleotide|DA 2010/12/29 06:00 |
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