Results
| PMID | 20677482 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | NF-kappaB, COX-2, TNF-alpha |
| Other associated phenotypes |
Endometriosis |
|
J Reprod Med. 2009 Oct;54(10):625-30. Kim, Young Ah| Kim, Ji Yeon| Kim, Mi Ran| Hwang, Kyung Joo| Chang, Doo Young| Jeon, Myung Kwon Department of Obstetrics and Gynecology and Clinical Research Center, Ilan Paik Hospital, Inje University, Ilsan, lorea. camanbal@paik.ac.kr OBJECTIVE: To investigate the role of NF-kappaB during the induction of COX-2 by TNF-alpha in the eutopic endometrium of women with and without endometriosis using stromal cell culture. STUDY DESIGN: Experimental study in cultured stromal cells of the eutopic endometrium of women with and without endometriosis in the presence of TNF-alpha. RESULTS: Within 5-20 minutes of stimulation with TNF-alpha, p-IkappaB was clearly observed in the eutopic endometrium of women with endometriosis and in that of women without endometriosis. COX-2 protein was significantly induced by treatment with TNF-alpha in both eutopic endometrial stromal cells of women with and without endometriosis (p < 0.05), but the degree of induction was significantly increased in eutopic endometrial stromal cells of women with endometriosis than those of women without endometriosis (p < 0.05). CONCLUSION: Overexpression of COX-2 by TNF-alpha in the eutopic endometrium of women with endometriosis may play a critical role in such pathophysiologic processes as endometriosis formation. Mesh Terms: Adult| Cells, Cultured| Cyclooxygenase 2/*biosynthesis| Endometriosis/*metabolism| Endometrium/cytology/metabolism| Female| Humans| NF-kappa B/*biosynthesis| Stromal Cells/*metabolism| Tumor Necrosis Factor-alpha/*pharmacology|DA 2010/09/16 06:00 |
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