Results
| PMID | 20797713 |
| Gene Name | HLA-DRB1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | CCL21 (rs2812378), HLA-DRB1 (rs660895) |
| Population size | 1149 |
| Population details | 1,149 samples (798 patients with endometriosis (176 minimal stage endometriosis, 116 mild endometriosis, 88 moderate stage endometriosis, 179 severe stage endometriosis ) and 351 controls) |
| Age | Control patients (aged 32+/-5 years; body mass index 23.4+/- 4), Endometriosis (aged 31 +/- 4 years; body mass index 23.2 +/- 4) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2011 Jan;95(1):437-40. doi: 10.1016/j.fertnstert.2010.07.1060. Sundqvist, Johanna| Falconer, Henrik| Seddighzadeh, Maria| Vodolazkaia, Alexandra| Fassbender, Amelie| Kyama, Cleophas| Bokor, Attila| Stephansson, Olof| Padyukov, Leonid| Gemzell-Danielsson, Kristina| D'Hooghe, Thomas M Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden. This study investigates the association of rheumatoid arthritis-associated single nucleotide polymorphisms in endometriosis. We found an association of CCL21 (rs2812378) and HLA-DRB1 (rs660895) with moderate to severe endometriosis. Mesh Terms: Adult| *Autoimmune Diseases/epidemiology/genetics/immunology| Chemokine CCL21/*genetics| *Endometriosis/epidemiology/genetics/immunology| Female| Genetic Predisposition to Disease/epidemiology| HLA-DR Antigens/*genetics| HLA-DRB1 Chains| Humans| |
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