Results
| PMID | 20864099 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | VEGF |
| Other associated phenotypes |
Endometriosis associated infertility |
|
Fertil Steril. 2011 Jan;95(1):360-2. doi: 10.1016/j.fertnstert.2010.08.040. Lee, Te-Ching| Ho, Han-Chen Institute of Physiological and Anatomical Medicine, Department of Anatomy, Tzu Chi University, and Department of Obstetrics and Gynecology, Yuli Veterans Hospital, Hualien, Taiwan. Significantly higher levels of prostaglandin E2 and vascular endothelial growth factor were associated with the severity of endometriosis. In this study, pathologic concentrations of prostaglandin E2 and vascular endothelial growth factor found in endometriotic women significantly inhibited sperm motility, acrosome reaction, and sperm-oocyte interaction, which might result in endometriosis-associated subfertility/infertility. Mesh Terms: Acrosome Reaction/drug effects/physiology| Animals| Cricetinae| Dinoprostone/*metabolism/pharmacology| Endometriosis/*physiopathology| Female| Humans| In Vitro Techniques| Infertility, Female/*physiopathology| Male| Neovascularization, Physiolog |
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