Results
| PMID | 21145050 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 20 |
| Population details | 20 (12 women with endometriosis, 8 control women) |
| Age | 25 to 43 years |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2011 Apr;95(5):1836-8. doi: 10.1016/j.fertnstert.2010.11.039. Epub Liu, Yuhuan| Hu, Jingjing| Shen, Wei| Wang, Jiaqi| Chen, Chao| Han, Jie| Zai, Dongxia| Cai, Zailong| Yu, Chaoqin Department of Chinese Traditional Medicine, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China. Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis. Mesh Terms: Adult| Ascitic Fluid/pathology/*physiology| *Cell Proliferation/drug effects| Cells, Cultured| Culture Media, Conditioned/pharmacology| Cyclooxygenase 2/*genetics/metabolism| Endometriosis/*pathology| Endometrium/cytology/drug effects/metabolism/*p |
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