Results
| PMID | 21160085 |
| Gene Name | TRPV1 |
| Condition | Endometriosis (Peritoneal) |
| Association |
Associated |
| Population size | 49 |
| Population details | 49 (28 of whom had chronic pelvic pain (CPP) and 21 without chronic pelvic pain (CPP)) |
| Sex | Female |
| Associated genes | TRPV1 |
| Other associated phenotypes |
Peritoneal endometriosis, pelvic pain |
|
Reprod Sci. 2011 Jun;18(6):511-5. doi: 10.1177/1933719110391279. Epub 2010 Dec Rocha, Marcelo Gondim| e Silva, Julio Cesar Rosa| Ribeiro da Silva, Alfredo| Candido Dos Reis, Francisco Jose| Nogueira, Antonio Alberto| Poli-Neto, Omero Benedicto Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. OBJECTIVE: To investigate the expression of capsaicin receptor (transient receptor potential vanilloid type 1 [TRPV1]) in the peritoneal endometriosis foci of women with and without chronic pelvic pain (CPP). METHODS: A case-control study was conducted on 49 women with endometriosis who underwent laparoscopy, 28 of whom had CPP and 21 without CPP. Samples from peritoneum of the rectouterine excavation (2 cm2) were obtained by laparoscopy, fixed in 4% formaldehyde, and underwent immunohistochemistry analysis using rabbit anti-TRPV1 (1:400) polyclonal antibody. RESULTS: Image analysis revealed that the immunoreactivity for TRPV1 was more frequent in specimens (endometriosis foci) from women with CPP (n = 15 of 28, 53.6%), compared to samples from the endometriosis foci of women without CPP (n = 6 of 21, 28.6%; P = .04). There was no correlation with duration, intensity of pain, or stage of the disease (endometriosis). DISCUSSION: The present study shows that TRPV1 expression in peritoneal endometriosis foci is related to CPP in women. However, this association is not related to the endometriosis stage. In view of the immunoreactivity for TRPV1 observed here, we believe that some endometriotic lesions may provide a scenario for TRPV1 to be tonically active and this activity may contribute to the underlying pathology of CPP. Mesh Terms: Adult| Case-Control Studies| Chronic Disease| Endometriosis/*metabolism/pathology| Female| Humans| Laparoscopy| Pelvic Pain/diagnosis/*metabolism/pathology| Peritoneum/*metabolism| Severity of Illness Index| TRPV Cation Channels/*metabolism|DA 2 |
|