Results
| PMID | 21529967 |
| Gene Name | FCRL3 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | FCRL3 (C-169T) |
| Population size | 334 |
| Population details | 334 (167 infertile women with endometriosis, 60 women with idiopathic infertility and 167 fertile women) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | FCRL3 |
| Other associated phenotypes |
Idiopathic infertility, infertility-related endometriosis |
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J Reprod Immunol. 2011 May;89(2):212-5. doi: 10.1016/j.jri.2011.02.007. Epub 2011 Teles, Juliana S| Bianco, Bianca| Vilarino, Fabia L| Andre, Gustavo M| Christofolini, Denise M| Barbosa, Caio P Division of Pathological Gynecology and Human Reproduction, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC (Santo Andre, Sao Bernardo do Campo and Sao Caetano do Sul County), Santo Andre, SP, Brazil. An aberrant immunological mechanism is thought to be involved in the pathogenesis of endometriosis. The present study aimed to determine whether there is a relationship between endometriosis and/or infertility and the FCRL3 C-169T polymorphism. This case-control study included 167 infertile women with endometriosis, 60 women with idiopathic infertility and 167 fertile women. Detection of the FCRL3 C-169T polymorphism was performed using TaqMan PCR. A significant difference in the genotype and allele frequencies of the FCRL3 C-169T polymorphism between endometriosis-related infertility (p=0.003 and p=0.001) and idiopathic infertility (p=0.027 and p=0.0185) versus controls was demonstrated. In conclusion, the results suggest that the FCRL3 C-169T polymorphism may play an important role in the pathogenesis of endometriosis and/or infertility. Mesh Terms: Adult| Case-Control Studies| Endometriosis/*genetics| Female| Gene Frequency/genetics| *Genetic Predisposition to Disease| Genotype| Humans| Infertility, Female/*genetics| *Polymorphism, Single Nucleotide| Promoter Regions, Genetic/*genetics| R |
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