Endometriosis Knowledgebase

PMID	21763649
Gene Name	TAGLN
Condition	Endometriosis
Association	Associated
Sex	Female
Associated genes	TAGLN
Other associated phenotypes	Endometriosis
TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation. Fertil Steril. 2011 Sep;96(3):700-3. doi: 10.1016/j.fertnstert.2011.06.052. Epub Dos Santos Hidalgo, Gabriela\| Meola, Juliana\| Rosa E Silva, Julio Cesar\| Paro de Paz, Claudia Cristina\| Ferriani, Rui Alberto Department of Gynecology and Obstetrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. ghidalgo@usp.br We found an increased expression of the TAGLN gene in endometriotic lesions compared with the eutopic endometrium of the same patients by real-time polymerase chain reaction. It is possible that this deregulation contributes to the development and maintenance of endometriosis by being involved in the pathways of organization of cytoskeletal architecture. Mesh Terms: Adult\| Cell Differentiation/physiology\| Cell Movement/physiology\| Endometriosis/pathology/physiopathology\| Endometrium/physiology\| Female\| Gene Expression Regulation/physiology\| Humans\| Microfilament Proteins/*genetics\| Middle Aged\| Muscle P