Results
| PMID | 21983734 |
| Gene Name | IL6 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-6 634C/G |
| Population size | 931 |
| Population details | 931 (432 Ems patients, 499 control women) |
| Sex | Female |
| Associated genes | IL-6 |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Oct;28(5):555-8. doi: Mao, Ting| Zong, Li-li| Wang, Yu-feng| Zhao, Xin| Fu, Yong-gui| Zeng, Jun| Rao, Xing-qiang Department of Gynecology and Obstetrics, Southern Medical University, Guangdong, People's Republic of China. OBJECTIVE: To investigate the association of interleukin 6 gene (IL-6) promoter region 634C/G (rs1800796) single nucleotide polymorphism (SNP) with the genetic susceptibility to endometriosis (Ems) in south Han Chinese women. METHODS: A case-control study was performed in 432 Ems patients and 499 control women to evaluate the SNP of IL-6 634C/G by using a fluorescent quantitative PCR-based high resolution melting (HRM) method. RESULTS: There were statistical significances in the IL-6 634C/G alleles, whether or not to carry allele G and genotype distributions between Ems patients and control women (P=0.032, 0.014 and 0.045, respectively). Allele C enhanced the risk of Ems 1.057 times while allele G reduced the risk of Ems 0.835 time. Carrying allele G reduced the risk of Ems 0.822 time, whereas not carrying allele G enhanced the risk of Ems 1.143 times. Compared with genotype CC, the risk of Ems with genotype CG reduced 0.704 time (95% CI: 0.533-0.931). There was no significant difference in whether or not carrying allele G distribution between Ems patients and control women (P=0.729). CONCLUSION: The present study demonstrated significant association between the SNP of IL-6 634C/G and genetic susceptibility to Ems in south Han Chinese women. Mesh Terms: Alleles| Case-Control Studies| Endometriosis/*genetics| Female| Genetic Predisposition to Disease/*genetics| Genotype| Humans| Interleukin-6/*genetics| Polymorphism, Single Nucleotide/*genetics|DA 2011/12/14 06:00 |
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