Results
| PMID | 22201911 |
| Gene Name | F2R |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | PAR1 |
| Other associated phenotypes |
Endometriosis |
|
Front Biosci (Elite Ed). 2012 Jan 1;4:755-67. Osuga, Yutaka| Hirota, Yasushi| Yoshino, Osamu| Hirata, Tetsuya| Koga, Kaori| Taketani, Yuji Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. yutakaos-tky@umin.ac.jp Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR(1) and PAR(2) are expressed in endometrial cells from the eutopic endometrium and endometriotic cells derived from endometriotic lesions. A typical activator of PAR(1), thrombin, and a typical activator of PAR(2), tryptase, are produced in the endometrium as well as endometriotic lesions. PAR(1) activation in endometrial stromal cells induces production of vascular endothelial growth factor and matrix metalloproteinases, and increases activities of tissue-type and urokinase-type plasminogen activator. PAR(2) activation in endometrial stromal cells stimulates interleukin (IL)-8 and stem cell factor production and proliferation of the cells. PAR(1) activation in endometriotic stromal cells induces production of IL-8, monocyte chemotactic protein-1, and cyclooxygenase-2, and proliferation of the cells. PAR(2) activation in endometriotic stromal cells increases secretion of IL-6 and IL-8, and the number of the cells. These findings indicate a wide range of function of PAR(1) and PAR(2) in the endometrium and endometriosis, and suggest PAR(1) and PAR(2) as possible therapeutic targets for endometriosis. Mesh Terms: Animals| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Receptor, PAR-1/*metabolism/physiology| Receptor, PAR-2/*metabolism/physiology|DA 2012/05/15 06:00 |
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