Results
| PMID | 22365076 |
| Gene Name | CSF1R |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | C-FMS, C-FMS |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2012 May;97(5):1129-35.e1. doi: 10.1016/j.fertnstert.2012.02.007. Budrys, Nicole M| Nair, Hareesh B| Liu, Ya-Guang| Kirma, Nameer B| Binkley, Peter A| Kumar, Shantha| Schenken, Robert S| Tekmal, Rajeshwar Rao Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, Texas 78229, USA. OBJECTIVE: To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. DESIGN: In vivo and vitro study. SETTING: University-based academic medical center. PATIENT(S): Reproductive-age women undergoing surgery for benign conditions. INTERVENTION(S): Peritoneal and endometrial tissue samples were obtained. MAIN OUTCOME MEASURE(S): CSF-1 and C-FMS expression. RESULT(S): Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. CONCLUSION(S): Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling. Mesh Terms: Academic Medical Centers| Ascitic Fluid/immunology| Cell Communication| Cells, Cultured| Coculture Techniques| Endometriosis/genetics/*immunology/pathology| Endometrium/*immunology/pathology| Epithelial Cells/immunology/pathology| Female| Humans| |
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