Results
| PMID | 22542989 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 142 |
| Population details | 142 (65 women with laparoscopically and histopathologically confirmed endometriosis, 40 women with pelvic adhesions, 37 control women without pelvic pathology) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2012 Jun;97(6):1380-6.e1. doi: 10.1016/j.fertnstert.2012.03.057. Barcz, Ewa| Milewski, Lukasz| Dziunycz, Piotr| Kaminski, Pawel| Ploski, Rafal| Malejczyk, Jacek Department of Obstetrics and Gynecology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland. OBJECTIVE: To evaluate inflammatory/angiogenic cytokines-interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, interferon-gamma (IFN-gamma), tumor necrosis factor (TNF), and vascular endothelial growth factor A (VEGF-A)-in the peritoneal fluid of patients with endometriosis in relation to the occurrence and severity of pelvic adhesions and in control women without pelvic pathology. DESIGN: Case-control study. SETTING: University research institution and hospital. PATIENT(S): Sixty-five women with laparoscopically and histopathologically confirmed endometriosis, including 40 women with pelvic adhesions, and 37 control women without pelvic pathology. INTERVENTION(S): Peritoneal fluid aspirated during routine diagnostic laparoscopic examination. MAIN OUTCOME MEASURE(S): Cytokines evaluated in the peritoneal fluid via specific enzyme-linked immunosorbent assays. RESULT(S): Endometriosis and the revised American Fertility Society score of this disease were associated with statistically significantly increased levels of peritoneal IL-6 and IL-8 whereas the incidence and score of endometriosis-related pelvic adhesions were negatively associated with increased levels of VEGF-A. Notably, the concentration of VEGF-A predicted adhesion development and severity after adjustment for endometriosis severity. The adhesion score also correlated with increased levels of IL-6; however, after adjustment for endometriosis severity, the effect of this cytokine was no longer statistically significant. CONCLUSION(S): Increased levels of VEGF-A may be associated with a decreased rate of pelvic adhesion formation in the course of endometriosis. Mesh Terms: Ascitic Fluid/immunology/*metabolism| Case-Control Studies| Cytokines/*metabolism| Endometriosis/immunology/*metabolism| Female| Humans| Interferon-gamma/metabolism| Interleukin-12/metabolism| Interleukin-1beta/metabolism| Interleukin-6/metabolis |
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