Results
| PMID | 22672593 |
| Gene Name | F2RL1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 62 |
| Population details | 62 (42 women with ovarian endometrioma, 20 endometrium tissues from women without endometriosis) |
| Sex | Female |
| Associated genes | TF, PAR-2 |
| Other associated phenotypes |
Endometriosis |
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Am J Reprod Immunol. 2012 Sep;68(3):251-7. doi: 10.1111/j.1600-0897.2012.01152.x. Lin, Min| Weng, Huinan| Wang, Xuefeng| Zhou, Bing| Yu, Ping| Wang, Yifeng Department of Obstetrics and Gynaecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China. PROBLEM: Little is known about the roles of TF and PAR-2 in endometriosis. This article investigated the expression of TF and PAR-2 in ectopic and eutopic endometrium with endometriosis and their relationship with the menstrual cycle. METHODS: Ectopic and eutopic endometrium tissues from 42 women with ovarian endometrioma and endometrium tissues from 20 women without endometriosis were obtained. All the samples were assessed for TF and PAR-2 protein location using immunohistochemistry and for relative TF and PAR-2 mRNA expression using real-time florescent quantitative polymerase chain reaction (FQ-PCR). RESULTS: Total TF and PAR-2 expression were significantly higher in ectopic and eutopic endometrium of women with endometriosis when compared with controls. Moreover, TF expression in ectopic and eutopic endometrium and PAR-2 expression in ectopic endometrium were significantly increased through the whole menstrual cycle. However, in eutopic endometrium with endometriosis, PAR-2 expression only in secretory phase was higher than its cycle-matched normal controls. There is no such difference in the proliferative phase. CONCLUSION: The abnormal co-upregulated expression of TF and PAR-2 in eutopic and ectopic endometrium may affect the development and growth of endometriotic lesions and highlighted the pathologic role of TF and PAR-2 in eutopic endometrium in endometriosis. Mesh Terms: Adult| Case-Control Studies| Endometriosis/*genetics/pathology| Endometrium/*metabolism/pathology| Female| Gene Expression| Humans| Immunohistochemistry| Menstrual Cycle/genetics| RNA, Messenger/biosynthesis| Real-Time Polymerase Chain Reaction| |
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