Results
| PMID | 23011643 |
| Gene Name | TIMP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 265 |
| Population details | 265 (194 patients affected by endometriosis, 71 patients with normal endometrium) |
| Sex | Female |
| Associated genes | MMP-2, MT1-MMP, TIMP-2 |
| Other associated phenotypes |
Implantation, endometriosis |
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Virchows Arch. 2012 Nov;461(5):589-99. doi: 10.1007/s00428-012-1301-4. Epub 2012 Londero, Ambrogio P| Calcagno, Angelo| Grassi, Tiziana| Marzinotto, Stefania| Orsaria, Maria| Beltrami, Carlo Alberto| Marchesoni, Diego| Mariuzzi, Laura Clinic of Obstetrics and Gynecology, University of Udine, Piazzale SM della Misericordia, 15-33100 Udine, Italy. In order to study survivin, matrix metalloproteinases (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor metalloproteinase-2 (TIMP-2) expression immunohistochemically in endometriotic tissues and normal endometrium, our retrospective study considered 194 patients affected by endometriosis and 71 patients with normal endometrium. Tissue microarrays were created from paraffin-embedded blocks; immunohistochemistry was used to assess protein expression. In endometriotic tissues, survivin was expressed at a higher level than in normal endometrium; its glandular expression level was higher in non-ovarian than in ovarian endometriotic tissues and lower in stromal components. Endometrial tissues from women without endometriosis and endometriotic tissues had different matrix metalloproteinase expression profiles. MMP-2 and MT1-MMP correlated with TIMP-2 in endometriotic tissues. Furthermore, in endometriotic tissues, expression of survivin, aurora B kinase, and Ki-67 showed a significant positive correlation, which indicates a role in cellular proliferation that could be closely linked to its anti-apoptotic activity in endometriosis development. Our results imply a role for matrix metalloproteinases in endometriosis invasiveness; correlation of their expression with that of TIMP-2 underscores its possible key regulatory role. Mesh Terms: Adult| Biomarkers/metabolism| Cell Proliferation| Cell Survival| Endometriosis/metabolism/*pathology| Endometrium/metabolism/*pathology| Female| Humans| Inhibitor of Apoptosis Proteins/*metabolism| Matrix Metalloproteinase 14/*metabolism| Matrix |
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