Results
| PMID | 23332132 |
| Gene Name | FOLR1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 18 |
| Population details | 18 patients with endometriosis |
| Age | 30.4± 5.2 years |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | CXCR4, EpCAM, ER, PR, VEGF-A, FR-?, HIF-1? |
| Other associated phenotypes |
Endometriosis |
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Int J Gynaecol Obstet. 2013 Apr;121(1):35-40. doi: 10.1016/j.ijgo.2012.10.025. van den Berg, Liseth L| Crane, Lucia M A| van Oosten, Marleen| van Dam, Gooitzen M| Simons, Arnold H M| Hofker, H Sijbrand| Bart, Joost Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. OBJECTIVE: To evaluate the expression of biomarkers in endometriotic tissue in order to determine the most promising molecules for targeted intraoperative imaging. METHODS: Tissue samples were obtained from 18 patients with endometriosis. The intensity and pattern of expression of the following biomarkers were assessed by immunohistochemistry: C-X-C chemokine receptor type 4 (CXCR4), epithelial cell adhesion molecule (EpCAM), estrogen receptor (ER), folate receptor alpha (FR-alpha), hypoxia-inducible factor 1-alpha (HIF-1alpha), progesterone receptor (PR), and vascular endothelial growth factor A (VEGF-A). The Target Selection Criteria scoring system was used to select the most promising biomarkers for intraoperative imaging. RESULTS: Expression of CXCR4, EpCAM, ER, PR, and VEGF-A was scored as strong in endometriotic epithelium. Expression of FR-alpha was detected in 94.4% of samples, whereas HIF-1alpha was expressed in just 5.6% of samples. Of note, CXCR4, ER, and VEGF-A were also expressed in surrounding healthy tissue, thus reducing the target-to-background ratio. CONCLUSION: Of the 7 biomarkers assessed in the present study, EpCAM, FR-alpha, and VEGF-A seem the most promising for targeted intraoperative imaging of endometriosis. Mesh Terms: Adult| Antigens, Neoplasm/*metabolism| Biomarkers/metabolism| Cell Adhesion Molecules/*metabolism| Endometriosis/*physiopathology| Epithelial Cell Adhesion Molecule| Female| Folate Receptor 1/*metabolism| Gene Expression| Humans| Immunohistochem |
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