Results
| PMID | 23474119 |
| Gene Name | CCL5 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | MCP-1, RANTES and MCP-3 |
| Population size | 95 |
| Population details | 95 (54 endometriosis, 41 controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(1):103-7. doi: Margari, Kalliopi-Maria| Zafiropoulos, Alexandros| Hatzidaki, Eleftheria| Giannakopoulou, Christina| Arici, Aydin| Matalliotakis, Ioannis Department of Neonatology, University of Crete, Greece. OBJECTIVE: To examine whether the levels of MCP-1, RANTES and MCP-3 in the peritoneal fluid correlate with endometriosis. STUDY DESIGN: Patients with endometriosis were compared with controls. SETTING: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. SUBJECTS: This study involved 95 women of reproductive age who were undergoing laparoscopy for evaluation of infertility or for pelvic pain. They were divided into an endometriosis group (n=54) and a control group (n=41). INTERVENTIONS: Peritoneal fluid samples were obtained and beta-chemokines (MCP-1, RANTES and MCP-3) were measured using ELISA. STATISTICAL ANALYSIS: Mean and median values were used to present values. Due to the non-normality of chemokines, a log transformation was applied. Differences were examined using independent samples t-test. One-way ANOVA and Tukey HSD multiple comparison post hoc tests were applied. A significance level at 0.05 was set. RESULTS: The levels of MCP-1 are higher (p for log values=0.024) in the control group (mean=687.6, SD=467.7 pg/ml) than those of the endometriosis group (mean=570.4, SD=633.1 pg/ml). The same is true for the median values of MCP-1 (control median=568.5, endometriosis median=384.7 pg/ml). MCP-3 and RANTES do not differ significantly (MCP-3 p=0.787, RANTES p=0.153). The levels of MCP-1 in patients with stage II endometriosis are significantly lower in comparison with stage III (p=0.048) and stage IV (p=0.033) endometriosis. CONCLUSIONS: A decrease in the concentrations of MCP-1 in stage I endometriosis has been observed, which is even larger in stage II, in contrast to stage III and stage IV endometriosis, which exhibit concentrations similar to the controls. Mesh Terms: Ascitic Fluid/*chemistry| Chemokine CCL2/*analysis| Chemokine CCL5/*analysis| Chemokine CCL7/*analysis| Endometriosis/*metabolism| Female| Humans|DA 2014/01/22 06:00 |
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