Results
| PMID | 23553197 |
| Gene Name | IL6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 78 |
| Population details | 78 (10 minimal to mild endometriosis, 26 moderate to severe endometriosis, 42 controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Arch Gynecol Obstet. 2013 Oct;288(4):805-14. doi: 10.1007/s00404-013-2828-6. Epub Wickiewicz, Dorota| Chrobak, Agnieszka| Gmyrek, Grzegorz B| Halbersztadt, Alicja| Gabrys, Marian S| Goluda, Marian| Chelmonska-Soyta, Anna First Department of Obstetrics and Gynecology, Wroclaw Medical University, Wroclaw, Poland. PURPOSE: To determine, with extended receiver operating characteristic (ROC) curve analysis, the diagnostic value of cytokines showing significantly different peritoneal concentrations between women with and without endometriosis. METHODS: Multiplex cytokine concentration measurement of IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma levels in peritoneal fluid of women with minimal to mild (n = 10) and moderate to severe (n = 26) endometriosis, and 42 controls. RESULTS: Only IL-6 and IL-10 concentrations were significantly higher in endometriosis patients than in controls. Specifically, significantly higher IL-6 and IL-10 levels were found in moderate to severe but not in minimal to mild endometriosis as compared to controls. For evaluation of diagnostic significance, ROC analysis determined discriminating parameters for IL-6, while those calculated for IL-10 were useless. Importantly, ROC analysis for IL-6 levels limited to women with moderate to severe endometriosis showed the highest area under the curve with the sample size sufficient to achieve 90 % power of the test. Finally, extended ROC including cost of analysis for this group of patients determined the optimal cut-off leading to high specificity and positive likelihood ratio resulting in 79 % effectiveness of the test. CONCLUSIONS: While our outcomes show moderate usefulness of peritoneal IL-6 levels in discrimination of moderate to severe endometriosis, further studies might be needed to determine the usefulness of peritoneal IL-6 levels in detection of early stages of endometriosis, as such a finding would be more relevant in clinical decision making. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Biomarkers/metabolism| Case-Control Studies| Cytokines/metabolism| Endometriosis/*diagnosis/metabolism| Female| Humans| Interleukin-10/metabolism| Interleukin-6/*metabolism| ROC Curve| Severity of Illness Index |
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