Results
| PMID | 23553198 |
| Gene Name | FCRL3 |
| Condition | Endometriosis realted infertility |
| Association |
Associated |
| Mutation | FCRL3 -169T>C polymorphism |
| Population size | 660 |
| Population details | 660 (141 infertile women with endometriosis, 519 fertile women) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | FCRL3 |
| Other associated phenotypes |
Endometriosis-related infertility |
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Arch Gynecol Obstet. 2013 Oct;288(4):799-804. doi: 10.1007/s00404-013-2829-5. Szczepanska, Malgorzata| Wirstlein, Przemyslaw| Holysz, Hanna| Skrzypczak, Jana| Jagodzinski, Pawel P Division of Reproduction, Department of Obstetrics, Gynecology and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland. OBJECTIVE: Recently, the FCRL3 -169T>C (rs7528684) single-nucleotide polymorphism (SNP) has been demonstrated to be a risk factor of endometriosis related infertility. We studied whether the FCRL -169T>C SNP can be associated with endometriosis-related infertility in a sample of the Polish population METHODS: Using PCR-RFLP analysis we genotyped 141 infertile women with endometriosis and 519 fertile women. FCRL3 transcript levels were determined by reverse transcription and real-time quantitative PCR analysis in CD19(+) B cells from women with endometriosis-associated infertility and fertile women RESULTS: We found a significantly increased frequency of the FCRL3 C/C genotype in women with endometriosis-associated infertility than controls [OR = 1.681 (95 % CI = 1.120-2.522, p = 0.0116, p corr = 0.0348)]. There was also a statistically increased frequency of the C/C and C/T genotypes in patients compared with controls [OR = 2.009 (95 % CI = 1.214-3.324, p = 0.0059, p corr = 0.0177)]. The p value of the chi (2) test for the trend observed for the FCRL3 -169T>C polymorphism was also statistically significant (p trend = 0.0012, p corr = 0.0036). We also found significantly increased FCRL3 transcript levels in carriers of the FCRL3 -169 CC vs TT and CT vs TT genotype both in women with endometriosis-related infertility (p = 0.012; p = 0.015) and fertile women (p = 0.017; p = 0.032) CONCLUSIONS: FCRL3 -169T>C polymorphism alters the expression of FCRL3 and can be a risk factor of endometriosis-related infertility. Mesh Terms: Adult| Case-Control Studies| Endometriosis/complications/*genetics| Female| Genetic Markers| *Genetic Predisposition to Disease| Genotype| Genotyping Techniques| Humans| Infertility, Female/*etiology/genetics| Odds Ratio| Poland| *Polymorphism |
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