Results
| PMID | 23670619 |
| Gene Name | CXCR4 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 18 |
| Population details | 18 ( 9 eutopic endometrial cells collected from females with endometriosis, 9 eutopic endometrial cells collected from females without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | CXCR4, SOX2, MET, CRMP2, Oct4 |
| Other associated phenotypes |
Endometriosis |
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Mol Med Rep. 2013 Jul;8(1):183-8. doi: 10.3892/mmr.2013.1469. Epub 2013 May 10. Hwang, Jin-Hee| Oh, Jin-Ju| Wang, Tao| Jin, Yong-Cheng| Lee, Jae-Sung| Choi, Jong-Ryeol| Lee, Kyu-Sup| Joo, Jong-Kil| Lee, Hong-Gu Department of Animal Science and Technology, College of Animal Bioscience & Technology, Konkuk University, Seoul 143701, Republic of Korea. Endometriosis is a gynecological disease defined as the presence of endometrial tissue outside the uterine cavity, which is caused by various factors. Proteomic analysis of two sets of eutopic endometrial cells collected from the menstrual blood of females with (n=6; n=3) or without (n=6; n=3) endometriosis was performed to identify novel potential biomarkers for endometriosis. The data revealed that samples from endometriosis patients had stem cell characteristics, as they had higher mRNA expression levels of octamer-binding transcription factor 4 (Oct-4), C-X-C chemokine receptor type 4 (CXCR4), SRY-box containing gene 2 (SOX2) and mesenchymal-epithelial transition factor (MET) compared with that of the normal controls. Three proteins, collapsin response mediator protein 2 (CRMP2), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) and myosin regulatory light polypeptide 9 (MYL9), were simultaneously identified from the two sets of samples from females with or without endometriosis by two-dimensional electrophoresis (2-DE). A difference in CRMP2 expression was confirmed with western blotting. Taken together, the results suggest that CRMP2 plays a role in the pathogenesis of endometriosis. Mesh Terms: Adult| Biomarkers/metabolism| Cell Differentiation/genetics| Endometriosis/genetics/*metabolism| Endometrium/*metabolism| Female| Gene Expression| Humans| Intercellular Signaling Peptides and Proteins/metabolism| Nerve Tissue Proteins/metabolism| |
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