Results
| PMID | 23690335 |
| Gene Name | HDAC1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 104 |
| Population details | 104 (74 endometriosis samples (27 ovarian endometriosis, 19 peritoneal endometriosis, 28 deep- infiltrating endometriosis), 30 normal endometrium controls) |
| Sex | Female |
| Associated genes | HDAC-1, HDAC-2/-3 |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2013 Dec;20(12):1416-22. doi: 10.1177/1933719113488450. Epub 2013 May Samartzis, Eleftherios P| Noske, Aurelia| Samartzis, Nicolas| Fink, Daniel| Imesch, Patrick 1Division of Gynecology, University Hospital Zurich, Zurich, Switzerland. Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS +/- standard deviation) was 7.6 +/- 2.5 in endometriosis and 5.3 +/- 2.3 in normal endometrium (P < .001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 +/- 0.7 and 11.8 +/- 1.1 in endometriosis and 11.6 +/- 1.0 and 11.9 +/- 0.4 in normal endometrium (P = .7 and P = .2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis. Mesh Terms: Case-Control Studies| Endometriosis/*enzymology| Estrogen Receptor alpha/analysis| Estrogen Receptor beta/analysis| Female| Histone Deacetylase 1/*analysis| Histone Deacetylase 2/analysis| Histone Deacetylases/analysis| Humans| Immunohistochemist |
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