Results
| PMID | 23793472 |
| Gene Name | PGRMC1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 34 |
| Population details | 34 (11 women with laparoscopically and/or histologically proven stage III/IV endometriosis, 23 disease-free women) |
| Sex | Female |
| Associated genes | PGRMC-1, PGRMC-2 |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2014 Feb;21(2):190-7. doi: 10.1177/1933719113492208. Epub 2013 Jun Bunch, Kristen| Tinnemore, Deborah| Huff, Seth| Hoffer, Zachary S| Burney, Richard O| Stallings, Jonathan D 1Department of Obstetrics/Gynecology, Madigan Army Medical Center, Tacoma, WA, USA. Endometriosis is a hormone-dependent inflammatory condition associated with pain and infertility. A growing body of evidence supports attenuated secretory-phase progesterone responsiveness in women with this disease. Herein, we compare the expression of progesterone receptor membrane components (PGRMC) 1 and 2 in eutopic endometrium from 11 women with laparoscopically and/or histologically proven stage III/IV endometriosis and 23 disease-free women. Menstrual cycle phase was determined using a combination of reported cycle day, serum hormone profile, and endometrial histologic dating. The PGRMC-1 (fold change -3.3; P < .05) and PGRMC-2 (fold-change -8.8; P < .05) gene expression were significantly downregulated in secretory phase, eutopic endometrium from women with endometriosis. Immunohistochemistry demonstrated decreased PGRMC-1 and PGRMC-2 protein expression in the secretory phase endometrial stroma cells of women with endometriosis. Consistent with the preclinical work of others, our results reflect downregulation of endometrial PGRMC-1 and PGRMC-2 expression in secretory phase endometrium from women with advanced stage endometriosis. Understanding the molecular mechanisms of attenuated progesterone action in endometriosis has important diagnostic and therapeutic implications. Mesh Terms: Adult| Endometriosis/diagnosis/*metabolism| Endometrium/*metabolism/pathology| Female| *Gene Expression Regulation| Humans| Membrane Proteins/*biosynthesis| Receptors, Progesterone/*biosynthesis| Retrospective Studies|DA 2014/07/16 06:00 |
|