Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 23799909
Gene Name PON1
Condition Endometriosis
Association Associated
Population size 80
Population details 80 (33 mild endometriosis, 47 moderate/severe endometriosis)
Sex Female
Infertility type Female infertility
Other associated phenotypes Endometriosis
There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study.

Reprod Health. 2013 Jun 22;10:32. doi: 10.1186/1742-4755-10-32.

Bragatto, Felipe Barca| Barbosa, Caio Parente| Christofolini, Denise Maria| Peluso, Carla| dos Santos, Aline Amaro| Mafra, Fernanda Abani| Cavalcanti, Viviane| Hix, Sonia| Bianco, Bianca

Division of Biochemistry, Department of Morphology, Faculdade de Medicina do ABC, Santo Andre, Santo Andre/SP, Brazil.

BACKGROUND: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). METHODS: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. RESULTS: The paraoxonase activity were 191.29 +/- 22.41 U/l in women with minimal/mild endometriosis and 224.85 +/- 21.50 U/l in women with moderate/severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 +/- 4.61 U/l in women with minimal/mild endometriosis and 90.78 +/- 3.43 U/l in moderate/severe disease (P = 0.888). CONCLUSIONS: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis.

Mesh Terms: Adult| Aryldialkylphosphatase/*blood| Endometriosis/*blood/complications/pathology| Female| Humans| Infertility, Female/complications| Oxidative Stress|DA 2013/11/10 06:00